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High-Purity Chelating Amine for Organometallic Catalysis & Fine Chemical Synthesis
|
Parameter
|
Specification
|
|---|---|
|
Chemical Name |
N,N,N′,N′-Tetramethylethylenediamine |
|
CAS Number |
110-18-9 |
|
Molecular Formula |
C₆H₁₆N₂ |
|
Molecular Weight |
116.21 g/mol |
|
Purity |
≥99.5% (GC) |
|
Appearance |
Colorless to pale yellow transparent liquid |
HIGH COORDINATION ACTIVITY
EXCELLENT PURITY & VOLATILITY CONTROL
FLEXIBLE BULK & SAMPLE PACKAGING
TUODA’s TMEDA is a premium-grade chelating diamine widely used in organolithium and Grignard chemistry. Known for its strong coordination ability, low moisture content, and excellent solubility, TMEDA enhances reactivity and selectivity across a range of metalation and alkylation processes.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) CAS 110-18-9 is a highly efficient bidentate ligand widely used in organometallic synthesis, especially in lithiation, metalation, and Grignard-type reactions. With its strong electron-donating ability and low steric hindrance, TMEDA facilitates the formation of stable metal-ligand complexes, improving selectivity and reactivity in both laboratory-scale R&D and industrial manufacturing.
Produced in GMP-certified facilities, our TMEDA undergoes rigorous fractional distillation and moisture control. Each batch is sealed under nitrogen and verified for ≥99.5% purity, ensuring excellent performance, low volatility loss, and consistent behavior in critical organometallic transformations.
Industry-Leading Quality Parameters for High-Purity N,N,N′,N′-Tetramethylethylenediamine
All specifications above are strictly validated through comprehensive quality assurance testing. Customized specifications and detailed documentation are available upon request.
Why TUODA’s N,N,N′,N′-Tetramethylethylenediamine Sets the Industry Standard
Industry-grade TMEDA with ≥99.5% purity ensures minimal water and peroxide content, reducing side reactions and enabling reliable results in metalation and complexation chemistry.
TUODA’s TMEDA is purified and sealed under inert gas to prevent degradation from oxygen and humidity, ensuring consistent performance in storage and use.
TMEDA acts as a powerful bidentate ligand and Lewis base, enhancing the reactivity of organolithium, Grignard, and metal-catalyzed systems.
With over 10 years of experience in amine handling and purification, our technical team delivers tailored guidance for TMEDA use in complex organic synthesis.
Experience the difference that industry-leading TMEDA can make in your catalytic processes
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) Versatile Role in Modern Industrial Processes
Primary application as a chelating ligand for organolithium and Grignard reagents, enhancing reactivity and selectivity in carbon-carbon bond formation reactions.
Used as a modifier for metallocene and Ziegler-Natta catalyst systems, improving catalyst solubility and providing enhanced control over polymer microstructure.
Facilitates regioselective metalation reactions and serves as a key reagent in the synthesis of complex pharmaceutical intermediates requiring controlled lithiation steps.
Acts as a coordination ligand and base in the synthesis of specialty chemicals, enabling selective transformations and improved yields in complex reactions.
Utilized as a bidentate ligand for transition metal complexes in catalytic systems, providing structural stability and tuning electronic properties of metal centers.
Essential reagent in academic and industrial research for developing novel synthetic methodologies and studying coordination chemistry of organometallic compounds.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) plays a crucial role in modern organometallic chemistry, particularly in breaking up aggregates of organolithium reagents to enhance their reactivity and selectivity in synthesis.
Our high-purity TMEDA ensures consistent performance in organometallic reactions, resulting in improved yields and selectivity for challenging transformations in both laboratory and industrial settings.
A leading pharmaceutical manufacturer implemented TUODA's TMEDA in their organolithium-mediated synthesis of a key heterocyclic intermediate, achieving 92% regioselectivity (up from 65%) and reducing side products by 40%, significantly enhancing process efficiency.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) serves as an important modifier in various polymerization catalyst systems, particularly for metallocene and Ziegler-Natta catalysts used in polyolefin production.
Our ultra-high purity TMEDA delivers consistent performance in catalyst modification, critical for producing polymers with precisely controlled properties and microstructure.
A specialty polymer producer incorporated our TMEDA as a co-catalyst modifier in their metallocene system for syndiotactic polystyrene production, achieving 25% higher catalyst efficiency and significantly improved polymer stereoregularity, resulting in enhanced product performance properties.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) serves as a critical reagent in pharmaceutical synthesis, enabling regioselective metalation reactions and complex transformations essential for API manufacturing.
Our pharmaceutical-grade TMEDA is produced under strict quality control, ensuring batch-to-batch consistency critical for validated pharmaceutical processes.
A major pharmaceutical company implemented our TMEDA in their manufacturing process for an antipsychotic drug intermediate, achieving 95% regioselectivity in a critical lithiation step and reducing production costs by 18% through improved process efficiency.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) is extensively used in fine chemical synthesis as a coordination ligand and base for various transformations requiring controlled reactivity and selectivity.
Our TMEDA provides consistent performance across diverse reaction conditions, critical for the production of high-value fine chemicals with precise specifications.
A leading electronic materials manufacturer implemented our TMEDA in their synthesis of a specialty conductive polymer precursor, achieving 99.2% purity and reducing production cycle time by 35% compared to their previous synthetic route.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) functions as an effective bidentate ligand for transition metal complexes, providing structural stability and tuning electronic properties in various catalytic systems.
Our industrial-grade TMEDA delivers reliable performance in metal complexation, with the purity and consistency required for reproducible catalyst preparation.
A specialty catalyst manufacturer utilized our TMEDA to develop a novel copper-TMEDA complex for Ullmann-type coupling reactions, achieving 88% yield in challenging substrate combinations and enabling a solvent-free process that significantly reduced waste generation.
N,N,N′,N′-Tetramethylethylenediamine (TMEDA) is an essential reagent in academic and industrial research laboratories, enabling the exploration of new synthetic methodologies and coordination chemistry of organometallic compounds.
We offer research-grade TMEDA in various package sizes suitable for laboratory use, with comprehensive safety documentation and technical support.
A university research group utilized our high-purity TMEDA to develop a new protocol for selective C-H functionalization of heterocycles, achieving unprecedented site-selectivity that led to a patent application and subsequent licensing to a major pharmaceutical company.
Discover how our high-purity N,N,N′,N′-Tetramethylethylenediamine (TMEDA) can enhance your specific application
Industry-Leading TMEDA With Proven Purity, Volatility, and Coordination Performance
| Chemical Formula: | C₆H₁₆N₂ |
| Molecular Weight: | 116.21 g/mol |
| CAS Number: | 110-18-9 |
|
Parameter
|
Standard Grade
|
High-Purity Grade
|
Ultra-Pure Grade
|
|---|---|---|---|
|
TMEDA Content |
≥ 99.0% |
≥ 99.5% |
≥ 99.9% |
|
Water Content |
≤ 0.3% |
≤ 0.1% |
≤ 0.05% |
|
Amine Impurities |
≤ 0.5% |
≤ 0.2% |
≤ 0.1% |
|
Color |
≤ 30 Hazen |
≤ 15 Hazen |
≤ 10 Hazen |
|
Heavy Metals (total) |
≤ 10 ppm |
≤ 5 ppm |
≤ 2 ppm |
|
Property
|
Value
|
|---|---|
|
Appearance |
Clear, colorless to slightly yellow liquid |
|
Density |
0.775 g/cm³ at 20°C |
|
Melting Point |
–55°C |
|
Boiling Point |
121°C at 760 mmHg |
|
Vapor Pressure |
1.6 kPa at 20°C |
|
Flash Point |
7°C (closed cup) |
|
Solubility |
Miscible with water, alcohols, ethers, and polar organic solvents |
TMEDA acts as a bidentate ligand with high electron-donating ability, forming stable complexes with transition metals and organolithium reagents. Handle under dry, inert conditions to prevent hydrolysis or air oxidation.
Highly hygroscopic and sensitive to ambient humidity. Use in dry boxes or under inert gas flow. Moisture contamination affects complexation performance.
Compatible with ether solvents (THF, diethyl ether), hydrocarbons, and aprotic polar solvents. Avoid mixing with strong acids or oxidizing agents.
Store in tightly sealed containers under nitrogen or argon. Recommended storage temperature: 0–25°C. Protect from heat, light, and moisture.
Our technical team is available to provide detailed specifications, safety information, and handling guidelines for our N,N,N′,N′-Tetramethylethylenediamine products.
Rigorous Testing and Strict Quality Management for Consistent Excellence
Each batch of incoming raw materials undergoes rigorous testing to verify purity and compliance with specifications before entering production.
Continuous monitoring throughout the production process with real-time analytics to ensure consistency and detect any deviations immediately.
Comprehensive analysis of each production batch against all specified parameters using advanced analytical techniques.
Application-specific testing to verify product performance in simulated customer processes, ensuring it meets real-world requirements.
Comprehensive documentation package including Certificate of Analysis, traceability records, and quality assurance documentation.
Our quality management system is certified to ISO 9001:2015, ensuring consistent processes and continuous improvement.
Environmental management certification demonstrating our commitment to sustainable manufacturing practices.
Occupational Health and Safety Management System certification for safe handling of hazardous materials.
Compliant with European Union's Registration, Evaluation, Authorization and Restriction of Chemicals regulation.
Our dedicated quality control laboratory is equipped with advanced analytical instruments to ensure the highest standards of product quality and consistency:
For precise determination of TMEDA purity and impurity profiles
To detect trace metal impurities down to ppb levels
For moisture content analysis with high sensitivity
For structural verification and identification of functional groups
To ensure consistent particle distribution in solid products
We partner with our customers to ensure our products meet their specific quality requirements through our comprehensive quality assurance program:
We develop custom specifications to match your unique process requirements.
Tailored quality standards are provided based on your end-use application.
We offer formulation flexibility to meet specialized technical demands.
Each product is adjusted to ensure compatibility with your production line.
Regulatory and safety parameters are aligned with your regional compliance.
Regulatory and safety parameters are aligned with your regional compliance.
Still have questions? Here are answers to the most common queries buyers ask when sourcing high-purity TMEDA.
Our standard MOQ is 200 kg (one drum), though smaller packaging units such as 20 kg or 1 kg samples are available upon request for R&D or pre-shipment evaluation.
Yes, we provide 100–500 g analytical-grade TMEDA samples with full COA and SDS for quality verification before bulk purchase.
TMEDA is classified as a flammable liquid (UN 2372) and must be transported under UN-compliant regulations. We offer certified packaging with nitrogen purging and full shipping documentation for international transport.
TMEDA is classified as a flammable liquid (UN 2372) and must be transported under UN-compliant regulations. We offer certified packaging with nitrogen purging and full shipping documentation for international transport.
Our TMEDA is manufactured under ISO 9001–certified processes. We also provide REACH pre-registration, RoHS compliance, and full COA, SDS, and TDS upon request.
Store TMEDA in sealed containers under nitrogen or argon, away from light, heat, and moisture. Recommended temperature: below 25°C. Avoid contact with acids and oxidizing agents.
We maintain regular stock of TMEDA in China and bonded warehouses abroad. Typical dispatch time:
In-stock: within 3–5 working days
Custom lots: within 10–14 working days
Yes. Our support includes:
Full documentation package (COA, SDS, TDS)
Usage guidance in organometallic synthesis or complexation
Response within 24 hours to technical inquiries
Purity ≥99.5% with <0.05% water content
Available in low-moisture, oxygen-free containers
Extensive experience in exporting amine ligands to Europe, India, Korea, and the U.S.
Customized service with competitive pricing and reliable logistics
Can’t find your question here? Our team is ready to assist you 1-on-1.
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